Introduction Group Research Publications Links Contacts
Peerreviewed publications 1998 - present
Demographic age shift toward later conception results
in an increased age in the subfertile population and
an increased demand for medical care. de Graaff AA, Land JA, Kessels AG,
Evers JL. Fertil Steril. (2010) in
press
Transforming growth factor beta1
gene -509 C/T polymorphism and endometriosis. Romano
A, van Kaam KJ, Dunselman GA. Fertil Steril. 2010 Jul 19. Letter to the editor.
Olfactomedin-4
regulation by estrogen in the human endometrium requires epidermal growth factor signalling. Dassen H, Punyadeera C, Schulkens I, Delvoux B, Marchetti C, Kamps R, Klomp J, Dijcks F, de Goeij A, DHooghe TM, Kyama CM, Ederveen A, DunselmanG, Groothuis P, Romano
A. Am J Path. (2010), in press
B lymphocyte stimulator -817C>T promoter polymorphism
and the predisposition to develop deep infiltrating endometriosis. de
Graaff A, Dunselman G, DelvouxB, van Kaam K, Smits L, Romano. Fertil Steril. 2010 94:1108-1110
Cyclin D1 regulates
hepatic estrogen and androgen metabolism. Mullany LK, Hanse EA, Romano A, Blomquist CH,
Mason JI, Delvoux B, Anttila
C, Albrecht JH. Am J Physiol Gastrointest Liver
Physiol. 2010 298:G884-95.
Identification of novel ER-α target genes in breast cancer cells: gene- and cell-selective
co-regulator recruitment at target promoters determines the response to 17b-estradiol
and tamoxifen. Romano A, Adriaens
M, Kuenen S, Delvoux B, Dunselman G, Evelo G, Groothuis P. Mol Cell Endocrinol. 2010 314:90-100.
Increased production of 17beta-estradiolin
endometriosis lesions is the result of impaired metabolism. Delvoux
B, Groothuis P, D'Hooghe T,
Kyama C, Dunselman G,
Romano A. J
Clin Endocrinol Metab. 2009 94(3):876-83.
Effects
of selective oestrogen receptor modulators on
proliferation in tissue cultures of pre- and postmenopausal human endometrium. Punyadeera C, Kamps R, Defrre S, Dijcks F, de Goeij A, Ederveen A, Dunselman G, Groothuis P. J
Steroid Biochem Mol Biol. 2008 112(1-3):102-9.
Fibromuscular
differentiation in deeply infiltrating endometriosis is a reaction of resident
fibroblasts to the presence of ectopic endometrium. van Kaam KJ, Schouten JP, Nap AW,
Oral contraceptives
prevent the development of endometriosis in the chicken chorioallantoic
membrane model. Nap AW, Groothuis PG, Punyadeera C,
Klein-Hitpass L, Kamps R, Delvoux B, Dunselman GA. Contraception. 2008 78(3):257-65.
Haemoglobin expression in human endometrium.
Dassen H, Kamps R, Punyadeera C, Dijcks F, de Goeij A,
Ederveen A, Dunselman G, Groothuis P. Hum
Reprod. 2008 23(3):635-41.
Estrogen metabolizing enzymes in endometrium and endometriosis.
Dassen H, Punyadeera C, Kamps R, Delvoux B, Van Langendonckt A, Donnez J, Husen B, Thole H, Dunselman G, Groothuis P. Hum
Reprod. 2007 22(12):3148-58.
Transforming growth factor beta1
gene polymorphism 509C/T in deep infiltrating endometriosis.
van Kaam KJ, Romano A,
Impact
of two functional Progesterone Receptor Polymorphisms (PRP): +331G/A and PROGINS on the cancer risks in familial breast/ovarian
cancer. Romano A, Baars M, Martens H, Brandao R, Detisch Y, Jongen E, Blok MJ, Lindsey P, Fischer D-C,
Gmez Garca EB.
Open Cancer J. 2007;1:1-8.
Estrogen and the endometrium:
lessons learned from gene expression profiling in rodents and human. Groothuis PG, Dassen HH, Romano
A, Punyadeera C. Hum
Reprod Update. 2007 13(4):405-17.
Review.
The PROGINS polymorphism of the human
progesterone receptor diminishes the response to progesterone. Romano A,
Delvoux B, Fischer DC, Groothuis P. J
Mol Endocrinol. 2007 38(1-2):331-50.
Identification of
novel antigens in blood vessels in rectovaginal endometriosis. Van
Langendonckt A, Punyadeera C, Kamps R, Dunselman G, Klein-Hitpass L, Schurgers
LJ, Squifflet J, Donnez J, Groothuis P. Mol Hum Reprod. 2007
13(12):875-86
Progesterone receptor polymorphism +331G/A
is associated with a decreased risk of deep infiltrating endometriosis. Van Kaam KJ, Romano A, Schouten JP, Dunselman GA, Groothuis PG. Hum
Reprod. 2007 22(1):129-35.
RASSF1A
methylation and K-ras and
B-raf mutations and recurrent endometrial cancer.
Pijnenborg JM, Dam-de Veen GC, Kisters N, Delvoux B, van
Engeland M, Herman JG, Groothuis PG. Ann Oncol. 2007 18(3):491-7.
A sensitive HPLC method for the assessment
of metabolic conversion of estrogens. Delvoux B, Husen B,
Aldenhoff Y, Koole L,Dunselman G, Thole H, Groothuis P. J
Steroid Biochem Mol Biol. 2007 104(3-5):246-51.
Progesterone regulation of
implantation-related genes: new insights into the role of oestrogen.
Dassen H, Punyadeera C, Kamps R, Klomp J, Dunselman G, Dijcks F, de Goeij A, Ederveen A, Groothuis P. Cell
Mol Life Sci. 2007 64(7-8):1009-32.
Two functionally relevant polymorphisms inthe human progesterone receptor gene (+331 G/A and progins) and the
predisposition for breast and/or ovarian cancer. Romano
A, Lindsey PJ, Fischer DC, Delvoux B, Paulussen AD, Janssen RG, Kieback DG. GynecolOncol.
2006 101(2):287-95.
Tibolone
and metabolites induce prolactin production in human
endometrial stromal cells in vitro: evidence for
cell-specific metabolism. Groothuis PG, De Gooyer
ME, ten Kate J, Menheere PP, Dunselman GA, de Goeij AF, Verbost P, Ederveen AG,
Kloosterboer HJ. J
Steroid Biochem Mol Biol. 2006 100(4-5):152-60.
Expression and regulation of vascular
endothelial growth factor ligands and receptors
during menstruation and post-menstrual repair of human endometrium.
Punyadeera C, Thijssen VL, Tchaikovski S, Kamps R, Delvoux B, Dunselman GA, de Goeij AF, Griffioen AW, Groothuis PG. Mol Hum Reprod. 2006 12(6):367-75.
TP53 overexpression in recurrent endometrial
carcinoma. Pijnenborg JM, van de Broek L, Dam de Veen GC, Roemen GM, de Haan J,
van Engeland M, Voncken JW, Groothuis PG. Gynecol Oncol. 2006 100(2):397-404.
Aberrations in the progesterone
receptor gene and the risk of recurrent endometrial carcinoma.
Pijnenborg JM, Romano A, Dam-de Veen GC, Dunselman GA,
Fischer DC, Groothuis PG, Kieback DG. J Pathol. 2005 205(5):597-605.
Vascular development in
endometriosis. Groothuis PG,
Nap AW, Winterhager E, Grmmer
R. Angiogenesis.2005;8(2):147-56. Review.
Molecular characterization of
soluble factors from human menstrual effluent that induce epithelial to mesenchymal transitions in mesothelial
cells. Demir AY,
Groothuis PG, Dunselman GA, Schurgers L, Evers JL, de Goeij AF. Cell Tissue Res. 2005 322(2):299-311.
Now you see them, now you don't. Evers JL, Dunselman GA, Groothuis P. Fertil Steril. 2005 84(1):31-2;
discussion 38-9. Review.
Angiostatic
agents prevent the development of endometriosis-like lesions in the chicken chorioallantoic membrane. Nap
AW, Dunselman GA, Griffioen AW, Mayo KH, Evers JL, Groothuis PG. Fertil Steril. 2005 83(3):793-5.
Oestrogen-modulated gene expression in the human endometrium. Punyadeera
C, Dassen H, Klomp J, Dunselman G, Kamps R, Dijcks F, Ederveen A, de Goeij A, Groothuis P. Cell
Mol Life Sci. 2005 62(2):239-50.
APC, beta-catenin,
and E-cadherin and the development of recurrent
endometrial carcinoma. Pijnenborg
JM, Kisters N, van Engeland M, Dunselman GA, de Haan J, de Goeij AF, Groothuis
PG. IntJ Gynecol Cancer. 2004 14(5):947-56.
Triphasic
pattern in the ex vivo response of human proliferative phase endometrium to oestrogens.
Punyadeera C, Dunselman
G, Marbaix E, Kamps R, Galant C, Nap A, Goeij A, Ederveen A, Groothuis P. J Steroid Biochem Mol
Biol. 2004 92(3):175-85.
Proteome analysis of human mesothelial cells during epithelial to mesenchymal
transitions induced by shed menstrual effluent. Demir
AY, Demol H, Puype M, de Goeij AF, Dunselman GA, Herrler A, Evers JL,
Vandekerckhove J, Groothuis PG. Proteomics.2004
4(9):2608-23.
Defective mismatch repair and the
development of recurrent endometrial carcinoma.
Pijnenborg JM, Dam-de Veen GC, de Haan J, van Engeland M,
Groothuis PG. Gynecol Oncol. 2004 94(2):550-9.
Inhibiting MMP activity prevents the
development of endometriosis in the chicken chorioallantoic
membrane model. Nap AW, Dunselman GA, de Goeij AF, Evers JL,
Groothuis PG. Hum
Reprod. 2004 19(10):2180-7.
Pathogenesis of endometriosis. Nap AW,
Groothuis PG, Demir AY, Evers JL, Dunselman GA. Best
Pract Res Clin Obstet Gynaecol. 2004
18(2):233-44.Review.
Antiangiogenesis therapy for endometriosis.
Nap AW, Griffioen AW, Dunselman
GA, Bouma-Ter Steege JC, Thijssen VL, Evers JL, Groothuis
PG. J
Clin Endocrinol Metab. 2004 89(3):1089-95.
Inhibition of endometrial
peritoneal attachment in the prevention and treatment of endometriosis.
Groothuis PG,
Etiology of endometriosis: hypotheses and
facts. Dunselman GA, Groothuis PG. Gynecol Obstet Invest. 2004;57(1):42-3. Review.
Menstrual effluent induces epithelial-mesenchymal transitions in mesothelial
cells. Demir AY, Groothuis PG, Nap AW, Punyadeera C,
de Goeij AF, Evers JL, Dunselman GA. HumReprod.
2004 19(1):21-9.
Oestrogen and progestin responses in human endometrium.
Punyadeera C, Verbost P, Groothuis P. J
Steroid Biochem Mol Biol. 2003 84(4):393-410. Review.
Tissue integrity is essential for ectopic
implantation of human endometrium in the chicken chorioallantoic membrane. Nap
AW, Groothuis PG, Demir AY, Maas JW, Dunselman GA, de Goeij AF, Evers JL. Hum
Reprod. 2003 18(1):30-4.
Endometrial angiogenesis
throughout the human menstrual cycle. Maas JW, Groothuis
PG, Dunselman GA, de Goeij AF, Struyker Boudier HA, Evers JL. Hum
Reprod. 2001 16(8):1557-61.
Development of endometriosis-like
lesions after transplantation of human endometrial fragments onto the chick
embryo chorioallantoic membrane.
Maas JW, Groothuis PG, Dunselman GA, de Goeij AF,
Struijker-Boudier HA, Evers JL. Hum
Reprod. 2001 16(4):627-31.
The Mesothelium,
Teflon or Velcro? Mesothelium in endometriosis
pathogenesis. Dunselman GA, Groothuis PG, de Goeij AF,
Evers JL. Hum Reprod. 2001 16(4):605-7. Review.
Menstruum induces changes in mesothelial cell
morphology. Koks CA, Demir Weusten AY, Groothuis PG, Dunselman GA, de Goeij AF,
Evers JL. Gynecol
Obstet Invest. 2000;50(1):13-8.
Morphological changes in mesothelial cells induced by shed menstrual endometrium in vitro are not primarily due to apoptosis or
necrosis. Demir Weusten AY, Groothuis PG, Dunselman GA,
de Goeij AF, Arends JW, Evers JL. Hum
Reprod. 2000 15(7):1462-8.
Matrix metalloproteinases
and their tissue inhibitors in antegradely shed menstruum and peritoneal fluid. Koks
CA, Groothuis PG, Slaats P, Dunselman GA, de Goeij AF, Evers JL. Fertil
Steril. 2000 73(3):604-12.
Adhesion of menstrual endometrium
to extracellular matrix: the possible role of integrin
alpha(6)beta(1) and laminin
interaction. Koks CA, Groothuis PG, Dunselman GA, de Goeij
AF, Evers JL. Mol
Hum Reprod. 2000 6(2):170-7.
Adhesion of human endometrial fragments
to peritoneum in vitro. Groothuis
PG, Koks CA, de Goeij AF, Dunselman GA, Arends JW, Evers JL. Fertil Steril. 1999
71(6):1119-24.
Adhesion of shed menstrual tissue in an
in-vitro model using amnion and peritoneum: a light and electron microscopic
study. Koks CA, Groothuis PG, Dunselman GA, de Goeij
AF, Evers JL. Hum
Reprod. 1999 14(3):816-22.
Adhesion of human endometrium
to the epithelial lining and extracellular matrix of amnion in vitro: an
electron microscopic study. Groothuis PG, Koks CA, de
Goeij AF, Dunselman GA, Arends JW, Evers JL. Hum
Reprod. 1998 13(8):2275-81.
2005. Johanna MA Pijnenborg.
The predictive value of molecular markers for recurrent
endometrial carcinoma.
2004. Ayse Yasemin Demir. The pathogenesis
of endometriosis: the endometrium mesothelium dialogue.
2004. Annemiek W
Nap. The pathogenesis of endometriosis: Sampson was right.
2002.
2001. Jacques WM Maas. Invasion
and angiogenesis in endometriosis experimental studies in the chick embryo chorioallontoic membrane.
2000. Carolien AM Koks.
Menstrual endometrium and the
development of endometriosis.
1995.Paul JQ van der Linden. On the pathogenesis of
endometriosis.
1988. Gerard AJ Dunselman.
Endometriosis clinical and experimental aspects.