Bruno Villoutreix, PhD

INSERM U648

Université Paris Diderot - Paris7

35 rue Hélène Brion - 75013 Paris

 

With Dr. Bruno Villoutreix we have established a longterm collaboration, and he has truely been, and still is, an inspiration to our laboratory. He has extensive experience in various aspects of structural bioinformatics, in particular those of blood coagulation proteins. Although at present he has broadened his focus to other research fields, we still collaborate in particular with respect to virtual ligand screening  techniques. Other members of his team, Maria Miteva and Olivier Sperandio, are also involved in these collaborative efforts.

 

 

Björn Dahlbäck, MD, PhD

Professor of Blood Coagulation Research

Department of Laboratory Medicine, division of Clinical Chemistry

Lund University

University Hospital, Malmö

Malmö, Sweden

 

With Prof. Björn Dahlbäck we have a collaboration on the structure function studies of coagulation factor V and its regulation by the protein C system. Prof. Dahlbäck is an authority with respect to factor V and is the discoverer of APC resistance. Besides his interest in coagulation and the complement system he has widened his scientific horizon ever since he discovered apolipoprotein M, a protein important to the lipoprotein physiology and the etiology of atherosclerotic disease.

 

 

Svetla Stoilova-McPhie, PhD

Division of Structural Biology, OPIC

Wellcome Trust Centre for Human Genetics

University of Oxford, Roosevelt Drive

Oxford OX3 7BN, UK

 

With Dr. Stoylova we have had a collaboration since 1999, in a structural genomics study in which we aim at gaining a better and more detailed insight into the 3D structure of coagulation factor V and its ligands. Dr. Stoylova is an expert in the EM based methods for solving (macromolecular) structures.

 

 

Cathy Hayward, MD, PhD

Department of Pathology and Molecular Medicine/Medicine

McMaster University

Hamilton, Ontario Canada

 

With Dr. Hayward we collaborate in the research of multimerin, a platelet protein discovered by Dr. Hayward and which has been shown to be a binding partner of coagulation factor V.

 

 

Jan Voorberg, PhD

Department of Plasma Proteins

Sanquin Research

Plesmanlaan 125

1066 CX  Amsterdam

 

With Dr. Voorberg we are currently performing pilot studies in the field of coagulation factor VIII research.

 

 

Paul E. Bock, Ph.D.

Department of Pathology

Vanderbilt University School of Medicine

Nashville, Tennessee, United States

 

Prof. Bock has visited the maastricht laboratory as a visiting professor during a sabbatical leave and has boosted the interest we have in using fluorescence techniques for quantitative measurements in the structure-function studies of coagulation factors as well as snake venoms. With respect to these common research interests we have started collaborations.

 

 

Chris Reutelingsperger

Department of Biochemistry

Maastricht University

 

Dr. Reutelingsperger, who heads a research group within the Biochemistry department is the discoverer of Annexin V, the protein that can bind specifically to phospolipid membranes that contain the net negatively phosphatidylserine. We are currently involved in a structure function study that tries to indentify key residues in the Annexin V molecule that are essential for its biological functions. Our unit supplies the bioinformatics input that forms the basis of these ongoing studies.

 

 

Ludovic Autin

Equipe de Bioinformatique Genomique et Moleculaire

INSERM U726, Universite Paris 7

Paris, FRANCE

 

Ludovic has visited the Maastricht lab, as a PhDstudent of the Villoutreix lab. Since then we collaborate mainly on the topic of the macromolecular organisations of coagulation proteins.

 

 

Esther Lutgens

Pathology Department

Academic Hospital Maastricht

Maastricht, the Netherlands

 

Together with Esther we are involved in the discovery and optimization of small molecules that may be used in the treatment of patients suffering from atherosclerosis.

 

 

Kees van 't Veer

Center for Experimental and Molecular Medicine and the Center for Infection and Immunity Amsterdam

AMC, Amsterdam, the Netherlands

 

With Kees we have an ongoing collaboration in the modelling and targetting of proteins involved in the immune system. So far several models have been produced, based on which, mutagenesis studies were performed that verified the correctness of our models.

 

 

Kenneth Segers

K.U.Leuven. Rega Institute for Medical Research Dept. Microbiology and Immunology, Div. Bacteriology

Leuven, Belgium

 

Kenneth, former member of our group and a good friend of ours is working in the field of antibiotics and antibiotics resistance. Together we have embarked upon a project to identify and optimize new molecules that can target bacteria, using a novel approach.

 

 

Jean Luc Pellequer

The group of Jean Luc and ours share an interest in blood coagulation protein structure. Using atomic force microscopy jean Luc is able to do fascinating things. We share materials and ideas in order to gain information on selected proteins.